Cytogenetic Violations in Blood Lymphocytes of Macaca mulatta Monkeys in the Long Term after Irradiation with Accelerated Krypton Ions

Cytogenetic Violations in Blood Lymphocytes of Macaca mulatta Monkeys in the Long Term after Irradiation with Accelerated Krypton Ions Full article

Journal

Biology Bulletin
ISSN: 1608-3059 , E-ISSN: 1062-3590

Output data

Year: 2024, Volume: 51, Number: 11, Pages: 3379-3388 Pages count : 10 DOI: 10.1134/S1062359024701425

Authors

Koshlan I.V. ^1,2 , Koshlan N.A. ¹ , Isakova M.D. ¹ , Melnikova Yu.V. ¹ , Belyaeva A.G. ³ , Perevezentsev A.A. ³ , Shtemberg A.S. ³ , Klotz I.N. ⁴ , Gvozdik T.E. ⁴ , Bugay A.N. ¹

Affiliations

1	Joint Institute for Nuclear Research, Dubna, Russia
2	Dubna State University, Dubna, Russia
3	State Scientific Center of the Russian Federation—Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia
4	Institute of Medical Primatology, National Research Center Kurchatov Institute, Sochi, Russia

Funding (1)

Ministry of Science and Higher Education of Russia

FMFR-2024-0036

A study has been conducted of cytogenetic violations that occur in blood lymphocytes of Macaca mulatta monkeys after local exposure of the hippocampal region to accelerated 78Kr ions at a dose of 3 Gy. Analysis revealed a low level of chromosomal aberrations in the control group of monkeys. The number of cells with chromosomal aberrations did not exceed 1.67%. The main fraction was chromatid-type aberrations. A cytogenetic analysis of peripheral blood lymphocytes of monkeys exposed to accelerated krypton ions revealed the maximum level of chromosomal aberrations 24 h after exposure, which exceeded the control level by 2.7 times. By day 96, the number of aberrations had decreased 1.7-fold. However, it still exceeded the control level. By 460 days, some animals showed a slight increase in the number of aberrations compared to the previous observation period. Over the long term, a number of irradiated animals showed deviations from the standard behavior of monkeys. Data on chromosomal aberrations in blood lymphocytes of monkeys and humans after in vitro irradiation with 170 MeV protons are compared. The relevance of this research is due to preparation for interplanetary manned flights.

Koshlan I.V. , Koshlan N.A. , Isakova M.D. , Melnikova Y.V. , Belyaeva A.G. , Perevezentsev A.A. , Shtemberg A.S. , Klotz I.N. , Gvozdik T.E. , Bugay A.N.
Cytogenetic Violations in Blood Lymphocytes of Macaca mulatta Monkeys in the Long Term after Irradiation with Accelerated Krypton Ions
Biology Bulletin. 2024. V.51. N11. P.3379-3388. DOI: 10.1134/S1062359024701425 OpenAlex

Submitted:	Jun 29, 2023
Accepted:	Mar 27, 2024

OpenAlex:

W4408491407

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