Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles

Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles Full article

Journal

npj Microgravity
ISSN: 2373-8065

Output data

Year: 2025, Volume: 11, Article number : 79, Pages count : 9 DOI: 10.1038/s41526-025-00531-7

Authors

Tordeur C. ^1,2,3,4 , Abdessater E. ^1,2,4 , Hossein A. ^1,3,4 , Righetti F. ⁵ , Sinitsyn V. ⁶ , Mershina E. ⁶ , Luchitskaya Elena Sergeevna ⁷ , Caiani E.G. ^5,8 , Faoro V. ^1,3,4 , Tank J. ⁹ , van de Borne P. ^1,2,4 , Migeotte P.-F. ¹ , Rabineau J. ^1,3,4,10

Affiliations

1	Laboratory of Physics and Physiology (LPHYS), Department of Cardiology, Hôpital Universitaire de Bruxelles - Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium
2	Faculty of Medicine, Université libre de Bruxelles, Brussels, Belgium
3	Research Unit in Cardio-Respiratory Physiology, Exercise & Nutrition, Faculty of Human Movement Sciences, Université libre de Bruxelles, Brussels, Belgium
4	Brussels Laboratory of the Universe (BLU-ULB), Université libre de Bruxelles, Brussels, Belgium
5	Electronics, Information and Bioengineering Dpt., Politecnico di Milano, Milan, Italy
6	Department of Radiology, Medical Educational and Scientific Center University Hospital, Lomonosov Moscow State University, Moscow, Russia
7	IBMP RAS
8	IRCCS Istituto Auxologico Italiano, San luca Hospital, Milan, Italy
9	Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany
10	Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Canada

Funding (1)

Ministry of Science and Higher Education of Russia

FMFR-2024-0042

Microgravity exposure induces cardiac deconditioning, primarily due to hypovolemia and inactivity.Animal models suggest microgravity may cause left ventricular (LV) papillary muscle atrophy, but thishas not been studied in humans. This study used MRI to assess LV papillary muscle mass and LVmorphology and function in nine male cosmonauts before and 6 ± 2 days after long-duration space

Tordeur C. , Abdessater E. , Hossein A. , Righetti F. , Sinitsyn V. , Mershina E. , Luchitskaya E.S. , Caiani E.G. , Faoro V. , Tank J. , van de Borne P. , Migeotte P.-F. , Rabineau J.
Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles
npj Microgravity. 2025. V.11. 79 :1-9. DOI: 10.1038/s41526-025-00531-7 OpenAlex

Submitted:

Aug 31, 2024

OpenAlex:

W4403131584

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