A Study of Resistance to Calcification of Bovine Jugular Veins with Coatings Deposited from Solutions in Carbonic Acid

A Study of Resistance to Calcification of Bovine Jugular Veins with Coatings Deposited from Solutions in Carbonic Acid Full article

Journal

Doklady Physical Chemistry
ISSN: 0012-5016 , E-ISSN: 1608-3121

Output data

Year: 2021, Volume: 496, Number: 1, Pages: 8-12 Pages count : 5 DOI: 10.1134/s0012501621010012

Tags

supercritical carbon dioxide, carbonic acid, bioprostheses, decellularization, calcification, chitosan, bisphosphonates

Authors

Chashchin I.S. ¹ , Petlenko A.A. ² , Zaitsev I.L. ³ , Bakuleva N.P. ⁴

Affiliations

1	Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russia
2	Moscow Institute of Physics and Technology, 141701, Dolgoprudny, Moscow oblast, Russia
3	Moscow State University, 119991, Moscow, Russia
4	Bakulev National Medical Research Center for Cardiovascular Surgery, Ministry of Health, 119049, Moscow, Russia

The resistance to calcification of bovine jugular veins (BJVs) coated by chitosan or bisphosphonate deposited from solutions in water/subcritical carbon dioxide (carbonic acid) system was studied for the first time. Samples of veins subjected to hybrid decellularization in supercritical CO2 and coated by chitosan and bisphosphonate deposited from solutions in carbonic acid at elevated pressure (P = 30 MPa) and at room temperature were studied. The calcification of the treated veins, especially bisphosphonate-coated ones, was found to decrease by  = 90 ± 5%, p < 0.05, in comparison with the generally accepted gold standard (BJVs cross-linked with glutaraldehyde and decellularized with sodium dodecyl sulfate). It was found that signifcant suppression of BJV calcification requires a combination of properties of the coating, namely, the ability to cover free aldehyde groups and the ability to suppress the growth of pathogenic microflora (antimicrobial activity).

Chashchin I.S. , Petlenko A.A. , Zaitsev I.L. , Bakuleva N.P.
A Study of Resistance to Calcification of Bovine Jugular Veins with Coatings Deposited from Solutions in Carbonic Acid
Doklady Physical Chemistry. 2021. V.496. N1. P.8-12. DOI: 10.1134/s0012501621010012 OpenAlex

Чащин И.С. , Петленко А.А. , Зайцев И.Л. , Бакулева Н.П.
Исследование устойчивости к кальцинозу яремных вен быка с покрытиями, нанесенными из растворов в угольной кислоте
Доклады Российской академии наук. Химия, науки о материалах. 2021. Т.496. №1. С.77-82. DOI: 10.31857/s2686953521010039 OpenAlex

Submitted:	Aug 17, 2020
Accepted:	Jan 11, 2021

OpenAlex:

W3153115247

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