Abstract: Dihydropyridine receptors (DHPR) participate in changes of the membrane potential during muscle unloading. We used nifedipine, a dihydropyridine derivative and Ca2+ antagonist, to study the role of L-type Ca2+ channels (Cav1.1, DHPR) in regulation of energy and Ca2+ metabolism and impact on functional properties of m. soleus during unloading. Male rats were divided into 3 groups (n = 16 in each group): vivarium control with placebo (C), 3-day hindlimb suspension with placebo (HS), and 3-day hindlimb suspension with intraperitoneal administration of the nifedipine (N). It was found that nifedipine administration during hindlimb suspension produced the following effects: (1) it decreased the ATP accumulation; (2) prevented the reduction of the maximum force of a single contraction and the time of contraction, and (3) prevented the increase in the content of intramitochondrial and myoplasmic calcium. Thus, DHPR participates in energy and Ca2+ metabolism and affects the functional properties of muscles.

Cite: Zaripova K.A. , Sharlo K.A. , Sidorenko D.A. , Tyganov S.A. , Belova S.P. , Nemirovskaya T.L.
Effect of DHPR on Functional Properties, Energy, and Ca2+ Metabolism of m. soleus during Unloading
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 2025. V.19. N4. P.498-503. DOI: 10.1134/S1990747825700503 OpenAlex

Dates:

Submitted:	Nov 15, 2024
Accepted:	Jul 6, 2025

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OpenAlex:

W7105659891

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