Interrelationship of NT-proBNP and ST2 cardiac biomarkers with cardiovascular functional parameters under conditions of head-down bed rest

Interrelationship of NT-proBNP and ST2 cardiac biomarkers with cardiovascular functional parameters under conditions of head-down bed rest Full article

Journal

Extreme Medicine
ISSN: 2713-2757 , E-ISSN: 2713-2765

Output data

Year: 2026, DOI: 10.47183/mes.2025-403

Authors

Popova O.V. ¹ , Kashirina D.N. ¹ , Stulova L.S. ¹ , Pastushkova L.K. ¹ , Larina I.M. ¹ , Rusanov V.B. ¹

Affiliations

1	Institute of Biomedical Problems of the Russian Academy of Sciences

Funding (2)

1	Ministry of Science and Higher Education of Russia	FMFR-2024-0032
2	Ministry of Science and Higher Education of Russia	FMFR-2024-0042

Introduction. Insufficient physical activity is a key risk factors in the development of cardiovascular diseases. Such a condition can be simulated by head-down tilt bed rest (HDBR) studies, which enable the investigation of pathophysiological changes in the heart. Previous HDBR experiments have identified structural alterations in the heart, including decreased arterial pressure, impaired autonomic regulation, and vascular remodeling. However, the molecular mechanisms underlying these processes remain poorly understood. Objective. To investigate links between functional parameters of the cardiovascular system and NT-proBNP and ST2 cardiac biomarkers. Materials and methods. The experiment involved six volunteers who were subjected to 21-day HDBR. The parameters of heart rate variability (HRV), dispersion mapping (ECG DM), as well as levels of NT-proBNP and ST2 protein concentrations in venous blood samples, were evaluated. The examination was conducted five days before the onset of HDBR, on Days 1, 10, and 20 during HDBR, and on Day 5 after the experimental exposure. All computations were performed using the Statistica 12 statistical software package. Results. The NT-proBNP protein concentration significantly decreased on Days 10 and 20 of the experiment, while the ST2 protein concentration was permanently decreasing from the first days of HDBR. The left ventricular depolarization index increased sharply in the middle of the study, although having returned to their baseline values by Day 5 after the cessation of the exposure. Sympathetic activity had increased by Day 20. Conclusions. Interrelationships between functional parameters of the cardiovascular system and cardiac biomarkers were established, which may indicate that HDBR triggers the activation of neurohumoral and metabolic regulatory circuits in the setting of increased sympathetic autonomic modulating effects.

Popova O.V. , Kashirina D.N. , Stulova L.S. , Pastushkova L.K. , Larina I.M. , Rusanov V.B.
Interrelationship of NT-proBNP and ST2 cardiac biomarkers with cardiovascular functional parameters under conditions of head-down bed rest
Extreme Medicine. 2026. DOI: 10.47183/mes.2025-403 OpenAlex

Published online:

Feb 3, 2026

OpenAlex:

W7128789983

Пока нет цитирований