Abstract: Erythroid precursors from the femoral bone marrow of Wistar rats were characterized after 30-day hindlimb suspension, fractionated γ-radiation, and their combination. After hindlimb suspension, the total content of myeloid CFU decreased; activity of erythroid differon also considerably suppressed, which manifested in a decrease in the number of erythroid burst-forming units and area of colonies formed by erythrocyte precursors. After irradiation and combined exposure to these two factors, no significant differences from the control were revealed; optical density of formed colonies slightly increased in all experimental groups. Thus, suppression of the erythroid lineage was most pronounced during hindlimb unloading. The combined effect of radiation and hindlimb suspension produced no appreciable negative effect on erythropoiesis in rat bone marrow.

Cite: Markina E.A. , Shtemberg A.S. , Buravkova L.B.
Combined Effects of Irradiation and Hindlimb Suspension on Erythroid Lineage Precursors from Rat Bone Marrow
Bulletin of Experimental Biology and Medicine. 2020. V.168. P.517-520. DOI: 10.1007/s10517-020-04744-6 WOS Scopus РИНЦ PMID OpenAlex

Original: Маркина Е.А. , Штемберг А.С. , Буравкова Л.Б.
Эритроидные предшественники из костного мозга крыс при комбинированном действии ионизирующего излучения и антиортостатического вывешивания
Бюллетень экспериментальной биологии и медицины. 2019. Т.168. №10. С.506-509. РИНЦ

Identifiers:

Web of science:	WOS:000527541200023
Scopus:	2-s2.0-85081626232
Elibrary:	43262272
PMID:	32147768
OpenAlex:	W3010131543

Citing: Пока нет цитирований

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