On the Substantiation of Dose-Modifying Factors DMFim and DMFdel, which Characterize Modification of the Immediate and Delayed Body Responses to Radiation by Combined Effects of Stress Factors during Long-Term Orbital and Exploration Missions Review
| Journal |
Human Physiology
ISSN: 1608-3164 , E-ISSN: 0362-1197 |
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| Output data | Year: 2023, Volume: 49, Number: 7, Pages: 758-771 Pages count : 14 DOI: 10.1134/s0362119723070149 | ||||
| Tags | space missions, radiation hazard, chemical air contamination in crewed spacecraft, weightlessness, synergy of spaceflight factors, functions of body systems in immediate and delayed periods, lifespan reduction | ||||
| Authors |
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| Affiliations |
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Funding (1)
| 1 | Ministry of Science and Higher Education of Russia | 65.2 |
Abstract:
A huge body of experimental data on the effects of radiation and other physical and residential factors in space missions was analyzed to substantiate the dose-modifying factor for the immediate response to radiation (DMFim) in the context of risk to a cosmonaut’s health and efficiency. DMFim lies in a range of 0.8–1.3. Currently, DMFim can be taken to be 1.0 in view of the rapid cell recovery in radiation-sensitive tissues, such as bone marrow, the gastrointestinal tract, the lens epithelium, and even the cerebral cortex, during prolonged exposure to protons of solar cosmic rays. The dose-modifying factor for the delayed response (DMFdel) was grounded by assuming that air chemical contamination and weightlessness would probably further affect the cosmonauts during long-term orbital and interplanetary missions. The DMFdel value was established using the calculated overall logarithmic index, which quantitatively estimates the level of stress to regulatory systems and the reduction of functional reserves of the body upon long-term exposure to stress factors. Acetone, acetaldehyde, and ethanol vapors present in crewed spacecraft at maximum admissible concentrations (MACs) may increase DMFdel to 1.5. Moreover, DMFdel should be taken to be 2.0 because synergy of microgravity and galactic cosmic ray (GCR) heavy nuclei threatens with morphological and functional disorders of the central nervous system, vascular damage, and cardiovascular diseases.
Cite:
Shafirkin A.V.
, Vasin A.L.
, Tatarkin S.V.
On the Substantiation of Dose-Modifying Factors DMFim and DMFdel, which Characterize Modification of the Immediate and Delayed Body Responses to Radiation by Combined Effects of Stress Factors during Long-Term Orbital and Exploration Missions
Human Physiology. 2023. V.49. N7. P.758-771. DOI: 10.1134/s0362119723070149 Scopus РИНЦ OpenAlex
On the Substantiation of Dose-Modifying Factors DMFim and DMFdel, which Characterize Modification of the Immediate and Delayed Body Responses to Radiation by Combined Effects of Stress Factors during Long-Term Orbital and Exploration Missions
Human Physiology. 2023. V.49. N7. P.758-771. DOI: 10.1134/s0362119723070149 Scopus РИНЦ OpenAlex
Dates:
| Published print: | Jan 26, 2024 |
| Published online: | Jan 26, 2024 |
Identifiers:
| Scopus: | 2-s2.0-85183380273 |
| Elibrary: | 65565361 |
| OpenAlex: | W4391266128 |
Citing:
Пока нет цитирований