Abstract: Hypokinesia leads to skeletal muscle atrophy due to the disruption of the balance between protein synthesis and protein degradation (Fluck and Hoppeler, 2003). One of the mechanisms regulating alterations of signalingpathways could be an accumulation of ATP during the first three days of unloading (Zaripova et al., 2021). Extracellular ATP is one of the major mediators of autocrine/paracrine signaling (Lazarowski et al., 2003). P2Y1 and P2Y2 receptors are sensors of the extracellular ATP concentration (Casas et al., 2014). P2Y2 receptors increase skeletal muscle atrophy and the activation of fibroblasts/fibrosis in damaged muscle (Chen et al., 2021). At present, there are no well-described functional differences between P2Y1 and P2Y2 receptors. The current study tested a hypothesis that ATPdependent signaling via P2Y1 and P2Y2 receptors is involved in the activation of unloading-induced signaling cascades. To test this hypothesis two purinergic receptor inhibitors were used during three days of soleus muscle unloading: P2Y1 receptor inhibitor MRS2179 and P2Y2 receptor inhibitor AR-C 118925XX.

Cite: Zaripova K. , Belova S. , Shenkman B. , Nemirovskaya T.
P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy
In compilation Proceedings of the 2023 ISGP meeting. – Frontiers Media SA., 2023. – C.83-91. – ISBN 978-2-8325-1247-0. DOI: 10.3389/978-2-8325-1247-0 OpenAlex

Dates:

Submitted:	Jul 2, 2023
Accepted:	Jul 7, 2023

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OpenAlex:

W4398242171

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