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Adaptive Changes in Human Leukocytes in Response to a Long-Term Stay in Antarctica Научная публикация

Журнал Human Physiology
ISSN: 1608-3164 , E-ISSN: 0362-1197
Вых. Данные Год: 2024, Том: 50, Номер: 4, Страницы: 416–429 Страниц : 14 DOI: 10.1134/S0362119724700865
Ключевые слова rDNA, SatIII, telomere repeat, NOX4, NRF2, Antarctica, apoptosis, oxidative stress
Авторы Veiko N.N. 1 , Ershova E.S. 1 , Malinovskaya E.M. 1 , Savinova E.A. 1 , Chudakova J.M. 1 , Eliseeva J.I. 1 , Kostyuk S.V. 1 , Sadova A.A. 2 , Shmarov V.A. 2 , Rykova M.P. 2 , Osetskiy N.Yu. 2 , Ponomarev S.A. 2
Организации
1 Bochkov Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, Russia
2 Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

Информация о финансировании (1)

1 Министерство науки и высшего образования Российской Федерации FMFR-2024-0039

Реферат: Oxidative stress and aging are known to alter the satellite III repeat (1q12) (SatIII(1q)) and telomere repeat (TR) copy numbers (CNs) in DNA of human cells. Extreme conditions of Antarctica could potentially affect the CNs of the repeats in human blood cells, the effect being possibly associated with inhibition of the antioxidant system and activation of apoptosis. The ribosomal DNA (rDNA), SatIII(1q), and TR repeat CNs were studied in leukocytes of 11 men who participated in an expedition to the Vostok Station from 2019 to 2020. To observe the dynamic changes in repeat CNs and the degree of repeat oxidation, six blood samples were taken: before the arrival in Antarctica and after 27, 85, 160, 270, and 315 days of wintering. To analyze the adaptive changes, expression levels were measured for the genes coding for BAX, BCL2, NOX4, NRF2, SOD1, and HIF1. A decrease in SatIII(1q) CN and an increase in TR CN were detected, while the rDNA CN remained stable in human blood cells during wintering. The changes, along with a decrease in the oxidation marker 8-oxodG in DNA, were associated with an increase in NOX4 activity, a decrease in NRF2 activity, and an increase in expression of the proapoptotic protein BAX. Wintering in Antarctica was therefore assumed to stimulate the adaptive response in the human body, including higher elimination of “ballast” cells with a higher level of DNA oxidation, a higher SatIII(1q) content, and a lower TR content from the bloodstream. An increase in ROS due to chronic NOX4 activation and a NRF2 blockage might play a significant role in the response.
Библиографическая ссылка: Veiko N.N. , Ershova E.S. , Malinovskaya E.M. , Savinova E.A. , Chudakova J.M. , Eliseeva J.I. , Kostyuk S.V. , Sadova A.A. , Shmarov V.A. , Rykova M.P. , Osetskiy N.Y. , Ponomarev S.A.
Adaptive Changes in Human Leukocytes in Response to a Long-Term Stay in Antarctica
Human Physiology. 2024. V.50. N4. P.416–429. DOI: 10.1134/S0362119724700865 Scopus OpenAlex
Оригинальная: Вейко Н.Н. , Ершова Е.С. , Малиновская Е.М. , Савинова Е.А. , Чудакова Ю.М. , Елисеева Ю.И. , Костюк С.В. , Садова А.А. , Шмаров В.А. , Рыкова М.П. , Осецкий Н.Ю. , Пономарёв С.А.
Адаптивные изменения в лейкоцитах человека в ответ на длительное пребывание в Антарктиде
Физиология человека. 2024. Т.50. №4. С.120-136. DOI: 10.31857/S0131164624040107 РИНЦ OpenAlex
Идентификаторы БД:
Scopus: 2-s2.0-85217737596
OpenAlex: W4407085927
Цитирование в БД: Пока нет цитирований
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