Modification of the Properties of Extracellular Matrix of Senescent Mesenchymal Stem Cells Научная публикация
| Журнал |
Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 , E-ISSN: 1573-8221 |
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| Вых. Данные | Год: 2023, Том: 175, Номер: 4, Страницы: 569-575 Страниц : 7 DOI: 10.1007/s10517-023-05905-z | ||
| Ключевые слова | multipotent mesenchymal stem cells; endothelial cells; extracellular matrix; cell senescence | ||
| Авторы |
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| Организации |
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Реферат:
Сell senescence leads to changes in the secretory activity of mesenchymal stem cells (MSC), including proteins of extracellular matrix (ECM). Here we studied the regulatory properties of ECM of senescent MSC in a model with endothelial cells (EC). EC were seeded onto a decellularized extracellular matrix of senescent MSC. Changes in cell morphology and a decrease in cell growth were observed. In addition, increased production of inflammatory chemokines MCP-1 and GROα and reduced synthesis of proangiogenic growth factor FGF-2 were revealed. Analysis of ECM showed quantitative and qualitative changes, including fibronectin layer morphology, total protein content, and concentration of deposited growth factors such as VEGF. Thus, our work demonstrates that senescence of MSC can lead to modification of the effects of their ECM on EC activity.
Библиографическая ссылка:
Matveeva D.K.
, Ezdakova M.I.
, Ratushnyy A.Y.
Modification of the Properties of Extracellular Matrix of Senescent Mesenchymal Stem Cells
Bulletin of Experimental Biology and Medicine. 2023. V.175. N4. P.569-575. DOI: 10.1007/s10517-023-05905-z WOS Scopus РИНЦ PMID OpenAlex
Modification of the Properties of Extracellular Matrix of Senescent Mesenchymal Stem Cells
Bulletin of Experimental Biology and Medicine. 2023. V.175. N4. P.569-575. DOI: 10.1007/s10517-023-05905-z WOS Scopus РИНЦ PMID OpenAlex
Оригинальная:
Матвеева Д.К.
, Ездакова М.И.
, Ратушный А.Ю.
Модификация свойств внеклеточного матрикса мезенхимных стромальных клеток при старении
Клеточные технологии в биологии и медицине. 2023. №2. С.119-125. DOI: 10.47056/1814-3490-2023-2-119-125 РИНЦ OpenAlex
Модификация свойств внеклеточного матрикса мезенхимных стромальных клеток при старении
Клеточные технологии в биологии и медицине. 2023. №2. С.119-125. DOI: 10.47056/1814-3490-2023-2-119-125 РИНЦ OpenAlex
Даты:
| Поступила в редакцию: | 4 апр. 2023 г. |
| Принята к публикации: | 31 авг. 2023 г. |
Идентификаторы БД:
| Web of science: | WOS:001074729200003 |
| Scopus: | 2-s2.0-85172802796 |
| РИНЦ: | 63419334 |
| PMID (PubMed): | 37770790 |
| OpenAlex: | W4387121587 |