Profound muscle atrophy in a patient with chronic disorders of consciousness for 13 years: case presentation

Profound muscle atrophy in a patient with chronic disorders of consciousness for 13 years: case presentation ArticleGenre_short.CASE_REPORT

Journal

Clinical Orthopedics and Trauma Care
, E-ISSN: 2694-0248

Output data

Year: 2024, Volume: 6, Number: 8, DOI: 10.31579/2694-0248/111

Tags

myopathy; skeletal muscles; chronic disturbance of consciousness; unresponsive wakefulness syndrome; clinical case

Authors

Skiteva Ekaterina ^1,2 , Sitovskaya Daria ^3,4 , Lesteva Natalia ¹ , Kondratieva Ekaterina ⁵ , Zabrodskaya Yulia ^3,6 , Kondratyev Anatoly ¹ , Shenkman Boris ²

Affiliations

1	Polenov Neurosurgical Institute – Branch of Almazov National Medical Research Centre, St. Petersburg, Russia
2	Institute of Medical and Biological Problems Russian Academy of Sciences, Moscow, Russia
3	Almazov National Medical Research Centre, St. Petersburg, Russia
4	Department of Pathology with a course of forensic medicine named after D.D. Lochov, St. Petersburg State Pediatric Medical University, Saint Petersburg, Russia
5	Military Medical Academy named after S.M. Kirov, St. Petersburg, Russia
6	Department of Pathology, Mechnikov North-West State Medical University, St. Petersburg, Russia

Chronic disorders of consciousness (CDC) are conditions that typically develop in patients after a coma and are characterized by wakefulness with a complete or almost complete absence of signs of purposeful behavior. This lack of purposeful behavior indicates a lack of awareness of one's own personality or the surrounding reality, and the disorder of consciousness must have persisted for at least 28 days. CDC includes two main categories: vegetative state or unresponsive wakefulness syndrome (VS/UWS) and minimally conscious state (MCS). It is important to note that with proper care and prevention of complications, patients with CDC can live for a long time at home or in palliative care centers, but they will be completely dependent on others. Additionally, most patients with CDC experience varying degrees of polyneuropathy and myopathy (known as myopathy of critical illness), which can impact their functional recovery. In this article, we present the skeletal muscle biopsy specimens of a patient who had been in a VS/UWS for 13 years. The patient, who was 45 years old at the time, suffered a hemorrhagic stroke in 2010, resulting in an intracerebral hematoma. Since then, the patient has remained in a vegetative state/areactive wakefulness syndrome and has been hospitalized in our center once a year for routine examinations and assessments of their level of consciousness.

Skiteva E. , Sitovskaya D. , Lesteva N. , Kondratieva E. , Zabrodskaya Y. , Kondratyev A. , Shenkman B.
Profound muscle atrophy in a patient with chronic disorders of consciousness for 13 years: case presentation
Clinical Orthopedics and Trauma Care. 2024. V.6. N8. DOI: 10.31579/2694-0248/111

Submitted:	Nov 1, 2024
Accepted:	Nov 8, 2024
Published print:	Nov 15, 2024

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