Cardiovascular Responses to Standing with and without Lower Body Compression Garments after Long-Duration Spaceflight
Научная публикация
| Журнал |
Journal of Applied Physiology
ISSN: 1522-1601
, E-ISSN: 8750-7587
|
| Вых. Данные |
Год: 2025,
Том: 139,
Номер статьи
: 1,
Страниц
: 11
DOI:
10.1152/japplphysiol.00646.2024
|
| Ключевые слова |
astronauts; cosmonauts; heart rate; International Space Station; orthostatic intolerance |
| Авторы |
Lee Stuart M.C.
1
,
Miller Annelise
2
,
Ribeiro L.Christine
1
,
Rosenberg Marissa
3
,
Miller Christopher A.
1
,
Laurie Steven S.
1
,
Young Millennia
4
,
Lytle Jason R.
1
,
Kofman Igor
1
,
Clement Gilles
1
,
Wood Scott
4
,
Rukavishnikov Ilya
5
,
Kitov Vladimir
5
,
Kozlovskaya Inessa
5
,
Tomilovskaya Elena
5
,
Reschke Millard
4
,
Macias Brandon R.
4
|
| Организации |
| 1 |
KBR
|
| 2 |
Aegis Aerospace
|
| 3 |
SpaceX
|
| 4 |
Johnson Space Center
|
| 5 |
Institute of Biomedical Problems
|
|
Информация о финансировании (1)
|
1
|
Министерство науки и высшего образования Российской Федерации
|
FMFR-2024-0033
|
Long-duration astronauts (>4 mo on the International Space Station, 87 total person-missions) participated in an orthostatic test consisting of 2 min of prone rest followed by 3.5 min of standing preflight, within hours of landing on the first day of recovery (R þ 0), and 1, 3, 7, 14, and 30 days after landing. Astronauts and cosmonauts performed exercise during spaceflight and fluid loading before landing to mitigate cardiovascular deconditioning. On R þ 0, astronauts participated in testing without compression garments or while wearing one of three garments designed to prevent orthostatic intolerance: Russian Kentavr, National Aeronautics and Space Administration’s gradient compression garment (GCG), or SpaceX’s gradient orthostatic protection garment (OPG). On R þ 0, the change in mean arterial pressure (DMAP) from prone to standing tended to decrease without compression garments ( 8 mmHg, P ¼ 0.053) and was less in astronauts wearing the Kentavr ( 5 mmHg, P ¼ 0.02), but not in crewmembers wearing the GCG or OPG. The heart rate response from prone to standing (DHR) on R þ 0 tended to increase in those not wearing compression garments (þ11 beats/min, P ¼ 0.051) and was greater when wearing the Kentavr (þ9 beats/min, P < 0.0001) or the OPG (þ10 beats/min, P ¼ 0.003), but not different in those wearing the GCG (þ1 beats/min, P ¼ 0.74). Although DHR when not wearing compression garments was greater (P < 0.05) for at least 2 wk after landing, DMAP was not different from preflight. Wearing NASA’s GCG mitigates cardiovascular stress during standing after long-duration spaceflight, and full recovery of orthostatic responses to standing without compression garments is not complete for weeks.