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Cardiovascular Responses to Standing with and without Lower Body Compression Garments after Long-Duration Spaceflight Научная публикация

Журнал Journal of Applied Physiology
ISSN: 1522-1601 , E-ISSN: 8750-7587
Вых. Данные Год: 2025, Том: 139, Номер статьи : 1, Страниц : 11 DOI: 10.1152/japplphysiol.00646.2024
Ключевые слова astronauts; cosmonauts; heart rate; International Space Station; orthostatic intolerance
Авторы Lee Stuart M.C. 1 , Miller Annelise 2 , Ribeiro L.Christine 1 , Rosenberg Marissa 3 , Miller Christopher A. 1 , Laurie Steven S. 1 , Young Millennia 4 , Lytle Jason R. 1 , Kofman Igor 1 , Clement Gilles 1 , Wood Scott 4 , Rukavishnikov Ilya 5 , Kitov Vladimir 5 , Kozlovskaya Inessa 5 , Tomilovskaya Elena 5 , Reschke Millard 4 , Macias Brandon R. 4
Организации
1 KBR
2 Aegis Aerospace
3 SpaceX
4 Johnson Space Center
5 Institute of Biomedical Problems

Информация о финансировании (1)

1 Министерство науки и высшего образования Российской Федерации FMFR-2024-0033

Реферат: Long-duration astronauts (>4 mo on the International Space Station, 87 total person-missions) participated in an orthostatic test consisting of 2 min of prone rest followed by 3.5 min of standing preflight, within hours of landing on the first day of recovery (R þ 0), and 1, 3, 7, 14, and 30 days after landing. Astronauts and cosmonauts performed exercise during spaceflight and fluid loading before landing to mitigate cardiovascular deconditioning. On R þ 0, astronauts participated in testing without compression garments or while wearing one of three garments designed to prevent orthostatic intolerance: Russian Kentavr, National Aeronautics and Space Administration’s gradient compression garment (GCG), or SpaceX’s gradient orthostatic protection garment (OPG). On R þ 0, the change in mean arterial pressure (DMAP) from prone to standing tended to decrease without compression garments ( 8 mmHg, P ¼ 0.053) and was less in astronauts wearing the Kentavr ( 5 mmHg, P ¼ 0.02), but not in crewmembers wearing the GCG or OPG. The heart rate response from prone to standing (DHR) on R þ 0 tended to increase in those not wearing compression garments (þ11 beats/min, P ¼ 0.051) and was greater when wearing the Kentavr (þ9 beats/min, P < 0.0001) or the OPG (þ10 beats/min, P ¼ 0.003), but not different in those wearing the GCG (þ1 beats/min, P ¼ 0.74). Although DHR when not wearing compression garments was greater (P < 0.05) for at least 2 wk after landing, DMAP was not different from preflight. Wearing NASA’s GCG mitigates cardiovascular stress during standing after long-duration spaceflight, and full recovery of orthostatic responses to standing without compression garments is not complete for weeks.
Библиографическая ссылка: Lee S.M.C. , Miller A. , Ribeiro L.C. , Rosenberg M. , Miller C.A. , Laurie S.S. , Young M. , Lytle J.R. , Kofman I. , Clement G. , Wood S. , Rukavishnikov I. , Kitov V. , Kozlovskaya I. , Tomilovskaya E. , Reschke M. , Macias B.R.
Cardiovascular Responses to Standing with and without Lower Body Compression Garments after Long-Duration Spaceflight
Journal of Applied Physiology. 2025. V.139. 1 :1-11. DOI: 10.1152/japplphysiol.00646.2024 PMID OpenAlex
Даты:
Поступила в редакцию: 21 авг. 2024 г.
Принята к публикации: 30 апр. 2025 г.
Опубликована online: 8 мая 2025 г.
Идентификаторы БД:
PMID (PubMed): 40338620
OpenAlex: W4410192192
Цитирование в БД: Пока нет цитирований
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