Abstract: The combined model of the effects of deep space flight factors, which was developed at the IBMP RAS, includes ground-based modeling of the chronic synchronous effects of hypogravity and gamma radia- tion, supplemented by heavy ion irradiation, a factor characteristic of interplanetary flights. At the behavioral level, the result of these factors is a spectrum of disorders in the emotional sphere while maintaining cognitive abilities. Neurochemical studies in rats show multidirectional changes in the metabolism of key neurotrans- mitters, primarily dopamine and serotonin, in the ancient brain and prefrontal cortex. At the molecular level, there are changes in the expression of genes encoding the corresponding receptors. A malfunction of the dopaminergic system apparently causes emotional and behavioral disorders. Folic acid, a precursor of dopa- mine, corrects these changes and, thus, opens up the possibility for further search for means of prevention and treatment of the emerging pathology.

Cite: Kuznetsova O.S. , Perevezentsev A.A. , Naplekova P.L. , Yasnetsov V.V. , Shtemberg A.S.
Molecular and Neurochemical Mechanisms of CNS Response to Combined Exposure to Model Factors of Spaceflight in Rodents
Neurochemical Journal. 2025. V.19. N3. P.422-430.

Dates:

Submitted:	Nov 11, 2024
Accepted:	Mar 17, 2025

Identifiers: No identifiers

Citing: Пока нет цитирований