Molecular and Neurochemical Mechanisms of CNS Response to Combined Exposure to Model Factors of Spaceflight in Rodents

Molecular and Neurochemical Mechanisms of CNS Response to Combined Exposure to Model Factors of Spaceflight in Rodents Научная публикация

Журнал

Neurochemical Journal
ISSN: 1819-7124 , E-ISSN: 1819-7132

Вых. Данные

Год: 2025, Том: 19, Номер: 3, Страницы: 422-430 Страниц : 9 DOI: 10.1134/S1819712425700461

Ключевые слова

radiation, space, magnetosphere, microgravity, neurochemical, molecular, rodents, dopamine

Авторы

Kuznetsova O.S. ¹ , Perevezentsev A.A. ¹ , Naplekova P.L. ^1,2 , Yasnetsov V.V. ¹ , Shtemberg A.S. ¹

Организации

1	IBMP RAS
2	Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia

Информация о финансировании (1)

Министерство науки и высшего образования Российской Федерации

FMFR-2024-0036

The combined model of the effects of deep space flight factors, which was developed at the IBMP RAS, includes ground-based modeling of the chronic synchronous effects of hypogravity and gamma radia- tion, supplemented by heavy ion irradiation, a factor characteristic of interplanetary flights. At the behavioral level, the result of these factors is a spectrum of disorders in the emotional sphere while maintaining cognitive abilities. Neurochemical studies in rats show multidirectional changes in the metabolism of key neurotrans- mitters, primarily dopamine and serotonin, in the ancient brain and prefrontal cortex. At the molecular level, there are changes in the expression of genes encoding the corresponding receptors. A malfunction of the dopaminergic system apparently causes emotional and behavioral disorders. Folic acid, a precursor of dopa- mine, corrects these changes and, thus, opens up the possibility for further search for means of prevention and treatment of the emerging pathology.

Kuznetsova O.S. , Perevezentsev A.A. , Naplekova P.L. , Yasnetsov V.V. , Shtemberg A.S.
Molecular and Neurochemical Mechanisms of CNS Response to Combined Exposure to Model Factors of Spaceflight in Rodents
Neurochemical Journal. 2025. V.19. N3. P.422-430. DOI: 10.1134/S1819712425700461 OpenAlex

Кузнецова О.С. , Перевезенцев А.А. , Наплёкова П.Л. , Яснецов В.В. , Штемберг А.С.
Молекулярные и нейрохимические механизмы реакции ЦНС грызунов на комбинированное воздействие модельных факторов космического полета
Нейрохимия. 2025. Т.42. №2. С.271-279. DOI: 10.7868/S3034556125020091 РИНЦ

Поступила в редакцию:	11 нояб. 2024 г.
Принята к публикации:	17 мар. 2025 г.

OpenAlex:

W7104937956

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