Реферат: During interplanetary flights, hypomagnetic conditions (HMC) may be one of the specific factors affecting the astronaut's body. Their combined effect with other factors of flight beyond low Earth orbit will greatly enhance the damaging effect on the body, including on the structural and functional state of the cardiovascular system (CVS). Our study was performed during a 12-month simulated isolation. It was attended by 6 healthy volunteers (2 men and 4 women). HMC (0.113 ± 0.062 µT) was modeled on -(2–4) days before the volunteers were placed in a hermetic facility and at the final stage of isolation (346–350) days of stay in a hermetic facility. Two 4-hour exposures with GMU exposure and background studies were conducted. Throughout their stay in the facility, each volunteer underwent continuous electrocardiogram (ECG) recording. The main indicators characterizing the autonomic modulating effects on the cardiovascular system changed in the HMC as follows: compared with the background, both women and men had higher heart rate in the HMC, VLF(mc ² ) and LF(mc ² ), as well as in men, the total power of the spectrum increased and prevailed in both exposures. When viewing ECG recordings in women, episodes of tachycardia were detected in the isolation exposure, as well as cardiac arrhythmias in the form of extrasystoles of ventricular and atrial origin, no cardiac arrhythmias were detected before isolation.In general, the strongest response of regulatory mechanisms associated with autonomic influences on the CVS in the HMC after 12 months of isolation was observed in women compared to men.

Библиографическая ссылка: Popova O.V. , Rusanov V.B. , Orlov O.I.
Mechanisms of Autonomic Regulation of the Human Cardiovascular System in Hypomagnetic Conditions After Simulated 12-Month Isolation
Microgravity Science and Technology. 2025. DOI: 10.21203/rs.3.rs-7046707/v1 OpenAlex

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