Oxygen Level Modifies the Expression of Genes Involved in the Epigenetic Regulation of Multipotent Stromal Cells In Vitro Full article
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Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 , E-ISSN: 1573-8221 |
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| Output data | Year: 2023, Volume: 175, Number: 3, Pages: 371-375 Pages count : 5 DOI: 10.1007/s10517-023-05870-7 | ||
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Abstract:
The work analyzes changes in the transcriptional activity of genes which are known to be involved in the epigenetic regulation of multipotent mesenchymal stromal cells (MSCs) in vitro depending on the level of oxygenation. DNA microarray analysis showed the most pronounced change in gene expression under 3% О2, including genes responsible for the MSCs epigenetic regulation. Fewer genes changed the expression under 1% О2 and minimal response was observed under 5% О2 as referenced to standard culture conditions (20% О2). Largest numbers were shown in the genes responsible for the histone regulation, while the genes whose products regulate chromatin, DNA and RNA were represented in a smaller number. Thus, the degree of hypoxia can modify the response of MSCs at the level of epigenetic regulators.
Cite:
P I Bobyleva
, Yu V Rudimova
, L B Buravkova
Oxygen Level Modifies the Expression of Genes Involved in the Epigenetic Regulation of Multipotent Stromal Cells In Vitro
Bulletin of Experimental Biology and Medicine. 2023. V.175. N3. P.371-375. DOI: 10.1007/s10517-023-05870-7 WOS Scopus РИНЦ PMID OpenAlex
Oxygen Level Modifies the Expression of Genes Involved in the Epigenetic Regulation of Multipotent Stromal Cells In Vitro
Bulletin of Experimental Biology and Medicine. 2023. V.175. N3. P.371-375. DOI: 10.1007/s10517-023-05870-7 WOS Scopus РИНЦ PMID OpenAlex
Original:
Бобылёва П.И.
, Рудимова Ю.В.
, Буравкова Л.Б.
Уровень кислорода in vitro модифицирует экспрессию генов, участвующих в эпигенетической регуляции мультипотентных стромальных клеток
Бюллетень экспериментальной биологии и медицины. 2023. Т.175. №3. С.355-359. DOI: 10.47056/0365-9615-2023-175-3-355-359 РИНЦ OpenAlex
Уровень кислорода in vitro модифицирует экспрессию генов, участвующих в эпигенетической регуляции мультипотентных стромальных клеток
Бюллетень экспериментальной биологии и медицины. 2023. Т.175. №3. С.355-359. DOI: 10.47056/0365-9615-2023-175-3-355-359 РИНЦ OpenAlex
Identifiers:
| Web of science: | WOS:001045668100008 |
| Scopus: | 2-s2.0-85167561327 |
| Elibrary: | 62419526 |
| PMID: | 37561376 |
| OpenAlex: | W4385715232 |