Реферат: Число соавторов 444 Research in context Evidence before this study Even with decades of substantial global investment, child growth failure (CGF) remains a leading risk factor associated with death and disability in children younger than 5 years. In the most recent global estimates of CGF burden, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 estimated that all CGF (mild, moderate, and severe) was associated with 774 000 deaths and 70·2 million DALYs in children younger than 5 years in 2021. Despite the crucial importance of understanding the causes and relative risks of negative health outcomes associated with CGF, global estimates of the increased relative risks of negative health outcomes associated with CGF typically rely on a synthetic review of 11 studies that were conducted between 1977 and 1997. Added value of this study Using updated estimates from GBD 2023 of both the relative risks of CGF associated with health outcomes as well as the proportion of children experiencing CGF, we present estimates of the global burden associated with CGF aggregated across mild, moderate, and severe forms for each of three CGF indicators: stunting (low height-for-age), underweight (low weight-for-age), and wasting (low weight-for-height). For each indicator, our estimates represent burden estimates for children that are at least 1 SD below the WHO Child Growth Standards. The length and quality of the studies included in the re-estimation of relative risks allowed for distinct quantification of the morbidity and mortality risk associated with each CGF indicator for lower respiratory infections, diarrhoea, measles, and malaria. In particular, using relative risks based on increased mortality alone, we found that more than 18% of all under-5 deaths were associated with CGF, with almost as many deaths associated with stunting as with wasting. Implications of all the available evidence Previous estimates of CGF identified wasting as the primary CGF risk factor associated with disease burden. We found that stunting is associated with almost as much of the global CGF burden as wasting and that stunting prevalence has decreased at a far slower rate than wasting over the past decades. Given the previously observed difficulty in a child recovering from stunting after their third month of life, our estimates should serve as a call to refocus efforts to avert CGF at the earliest stages of onset.

Библиографическая ссылка: Artamonov A.A.
Quantifying the fatal and non-fatal burden of disease associated with child growth failure, 2000–2023: a systematic analysis from the Global Burden of Disease Study 2023
The Lancet Public Health. 2026. V.10. N1. P.22-38. DOI: 10.1016/s2352-4642(25)00303-7 OpenAlex

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