Astronaut omics and the impact of space on the human body at scale | Sciact

Astronaut omics and the impact of space on the human body at scale Научная публикация

Журнал

Nature communications
ISSN: 2041-1723

Вых. Данные

Год: 2024, Том: 15, Номер: 1, Номер статьи : 4952, Страниц : DOI: 10.1038/s41467-024-47237-0

Авторы

Rutter Lindsay A. ^1,2,21 , Cope Henry ³ , MacKay Matthew J. ^4,5,6 , Herranz Raúl ⁷ , Das Saswati ⁸ , Ponomarev Sergey A. ⁹ , Costes Sylvain V. ¹⁰ , Paul Amber M. ¹¹ , Barker Richard ¹² , Taylor Deanne M. ^13,14 , Bezdan Daniela ^15,16,17 , Szewczyk Nathaniel J. ^3,18 , Muratani Masafumi ^1,2 , Mason Christopher E. ^4,5,6,19 , Giacomello Stefania ²⁰

Организации

1	Transborder Medical Research Center, University of Tsukuba, 305-8575 Tsukuba, Japan
2	Department of Genome Biology, Institute of Medicine, University of Tsukuba, 305-8575 Tsukuba, Japan
3	School of Medicine, University of Nottingham, Derby, DE22 3DT UK
4	Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065 USA
5	The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021 USA
6	The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10065 USA
7	Centro de Investigaciones Biológicas “Margarita Salas” (CSIC), Ramiro de Maeztu 9, Madrid, 28040 Spain
8	Department of Biochemistry, Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, 110001 India
9	Department of Immunology and Microbiology, Institute for the Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia
10	Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035 USA
11	Embry-Riddle Aeronautical University, Department of Human Factors and Behavioral Neurobiology, Daytona Beach, FL 32114 USA
12	Department of Botany, University of Wisconsin-Madison, Madison, WI 53706 USA
13	Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104 USA
14	Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
15	Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, 72076 Germany
16	NGS Competence Center Tübingen (NCCT), University of Tübingen, Tübingen, 72076 Germany
17	yuri GmbH, Meckenbeuren, 88074 Germany
18	Ohio Musculoskeletal and Neurological Institute (OMNI), Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701 USA
19	The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065 USA
20	SciLifeLab, KTH Royal Institute of Technology, Stockholm, 17165 Sweden
21	Present Address: School of Chemistry, University of Glasgow, Glasgow, G12 8QQ UK

Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in the human body. Here, we propose that a parallel Human Cell Space Atlas could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit could permit an advent of precision spaceflight healthcare. Alongside the scientific potential, we consider the complex ethical, cultural, and legal challenges intrinsic to the human space omics discipline, and how philosophical frameworks may benefit from international perspectives.

Rutter L.A. , Cope H. , MacKay M.J. , Herranz R. , Das S. , Ponomarev S.A. , Costes S.V. , Paul A.M. , Barker R. , Taylor D.M. , Bezdan D. , Szewczyk N.J. , Muratani M. , Mason C.E. , Giacomello S.
Astronaut omics and the impact of space on the human body at scale
Nature communications. 2024. V.15. N1. 4952 . DOI: 10.1038/s41467-024-47237-0 WOS Scopus РИНЦ PMID PMCID OpenAlex

Web of science:	WOS:001245213500055
Scopus:	2-s2.0-85191073784
РИНЦ:	67698789
PMID (PubMed):	38862505
PMCID (PubMed Central):	PMC11166943
OpenAlex:	W4399535260

БД	Цитирований
OpenAlex	11
Scopus	6