Bone loss recovery in mice following microgravity with concurrent bone-compartment-specific osteocyte characteristics

Bone loss recovery in mice following microgravity with concurrent bone-compartment-specific osteocyte characteristics Научная публикация

Журнал

European Cells & Materials
ISSN: 1473-2262

Вых. Данные

Год: 2021, Том: 42, Страницы: 220-231 Страниц : 12 DOI: 10.22203/eCM.v042a16

Авторы

Kroge S von ² , Wölfel E M ^2,3 , Buravkova LB ¹ , Atiakshin D A ^4,5 , Markina EA ¹ , Schinke T ² , Rolvien T ^2,6 , Busse B ^2,3 , Jähn-Rickert K ^2,7

Организации

1	IBMP RAS
2	Department of Osteology and Biomechanics, University Medical Centre Hamburg-Eppendorf, Lottestrasse 55a, 22529 Hamburg, Germany
3	Interdisciplinary Competence Centre for Interface Research (ICCIR), Forum Medical Technology Health Hamburg (FMTHH), Hamburg, Germany
4	Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples’ Friendship University of Russia, Moscow, Russia
5	Institute of Experimental Biology and Medicine, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia
6	Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
7	Mildred Scheel Cancer Career Centre Hamburg, University Cancer Centre Hamburg, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

Space missions provide the opportunity to investigate the influence of gravity on the dynamic remodelling processes in bone. Mice were examined following space flight and subsequent recovery to determine the effects on bone compartment-specific microstructure and composition. The resulting bone loss following microgravity recovered only in trabecular bone, while in cortical bone the tissue mineral density was restored after only one week on Earth. Detection of TRAP-positive bone surface cells in the trabecular compartment indicated increased resorption following space flight. In cortical bone, a persistent reduced viability of osteocytes suggested an impaired sensitivity to mechanical stresses. A compartment-dependent structural recovery from microgravity-induced bone loss was shown, with a direct osteocytic contribution to persistent low bone volume in the cortical region even after a recovery period. Trabecular recovery was not accompanied by changes in osteocyte characteristics. These post-space-flight findings will contribute to the understanding of compositional changes that compromise bone quality caused by unloading, immobilisation, or disuse.

Kroge S.v. , Wölfel E.M. , Buravkova L. , Atiakshin D.A. , Markina E. , Schinke T. , Rolvien T. , Busse B. , Jähn-Rickert K.
Bone loss recovery in mice following microgravity with concurrent bone-compartment-specific osteocyte characteristics
European Cells & Materials. 2021. V.42. P.220-231. DOI: 10.22203/eCM.v042a16 WOS Scopus РИНЦ PMID OpenAlex

Web of science:	WOS:000715851600001
Scopus:	2-s2.0-85118403617
РИНЦ:	48765181
PMID (PubMed):	34642917
OpenAlex:	W3205726160

БД	Цитирований
Scopus	9
OpenAlex	10