Weightlessness leads to an increase granulosa cells in the growing follicle

Weightlessness leads to an increase granulosa cells in the growing follicle Full article

Journal

npj Microgravity
ISSN: 2373-8065

Output data

Year: 2024, Volume: 10, Number: 1, DOI: 10.1038/s41526-024-00413-4

Authors

Kikina Anna Yu. ¹ , Matrosova Mariia S. ^2,3 , Gorbacheva Elena Yu. ^4,5 , Gogichaeva Ksenia K. ⁴ , Toniyan Konstantin A. ^4,5 , Boyarintsev Valery V. ⁶ , Kotov Oleg V. ⁴ , Ogneva Irina V. ^4,7

Affiliations

1	Gagarin Research and Test Cosmonaut Training Center, 141160, Star City, Moscow Region, Russia
2	Radiology Department, European Medical Center, 129090, Moscow, Russia
3	Research Center of Neurology, 125367 Moscow, Russia.
4	Cell Biophysics Lab, State Scientific Center of the Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences, 123007, Moscow, Russia
5	Gynecology Department, FGBU KB1 (Volynskaya) UDP RF, 121352 Moscow, Russia
6	Emergency and Extreme Medicine Department, Central State Medical Academy UDP RF, 121359, Moscow, Russia
7	Medical and Biological Physics Department, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia

Funding (1)

Ministry of Science and Higher Education of Russia

FMFR-2024-0041

The participation of women in space programs of increasing flight duration requires research of their reproductive system from the perspective of subsequent childbearing and healthy aging. For the first time, we present hormonal and structural data on the dynamics of recovery after a 157-day space flight in a woman of reproductive age. There were no clinically significant changes in the reproductive system, but detailed analysis shows that weightlessness leads to an increase in the proportion of early antral follicles and granulosa cells in large antral follicles. Returning to Earth’s gravity reduces the number and diameter of early antral follicles.

Kikina A.Y. , Matrosova M.S. , Gorbacheva E.Y. , Gogichaeva K.K. , Toniyan K.A. , Boyarintsev V.V. , Kotov O.V. , Ogneva I.V.
Weightlessness leads to an increase granulosa cells in the growing follicle
npj Microgravity. 2024. V.10. N1. DOI: 10.1038/s41526-024-00413-4 WOS Scopus РИНЦ PMID PMCID OpenAlex

Web of science:	WOS:001251889900002
Scopus:	2-s2.0-85196665530
Elibrary:	68290047
PMID:	38909072
PMCID:	PMC11193763
OpenAlex:	W4399916832

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