Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions

Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions Научная публикация

Журнал

Life Sciences in Space Research
ISSN: 2214-5532 , E-ISSN: 2214-5524

Вых. Данные

Год: 2022, Номер: 33, Страницы: 7-12 Страниц : 6 DOI: 10.1016/j.lssr.2022.01.001

Ключевые слова

Cosmonaut Secondary hemorrhagic purpura Long-term space mission +Gx forces Proteomics Blood proteome

Авторы

Пастушкова Людмила Ханифовна ¹ , Гончаров Игорь Николаевич ¹ , Колотева Милена Ильинична ¹ , Гончарова Анна Георгиевна ¹ , Каширина Дарья Николаевна ¹ , Носовский Андрей Максимович ¹ , Глебова Татьяна Михайловна ¹ , Kononikhin A.S. ^1,2 , Borchers C.H. ² , Nikolaev E.N. ² , Ларина Ирина Михайловна ¹

Организации

1	SSC RF - Institute of Biomedical Problems of RAS, Khoroshevskoe shosse, 76A, 123007, Moscow, Russia
2	Skolkovo Institute of Science and Technology, st. Nobel, 3, 121205, Moscow, Russia

Информация о финансировании (2)

1	Министерство науки и высшего образования Российской Федерации	65.1
2	Министерство науки и высшего образования Российской Федерации	65.3

The interest in the role of the gravitational factor during landing after long-term space flights (SF) leads to the search for various innovative approaches to assessing the compliance of external changes observed by clinicians. The results of special research methods such as Omics technologies that may reflect physiological responses to the conditions created during landing are of great interest. Our purpose is to compare the blood plasma proteome changes associated with the trauma and endothelial dysfunction processes prior to launch and on the day of landing, as well as the groups of cosmonauts with and without the secondary hemorrhagic purpura. In our study, the concentrations of 125 plasma proteins in 18 Russian cosmonauts, measured using targeted proteomic analysis based on liquid chromatography and tandem mass spectrometry were analyzed. The results reveal the trends of 12 proteins participating in the processes that trigger hemorrhagic purpura under the effect of re-entry g-forces. Exposure to intense g-forces and return to the gravity are the key factors for external manifestations of changes in the body systems induced by a long-term stay in space microgravity. Our results may be useful for further research to experts in gravitational physiology, aviation and space medicine.

Пастушкова Л.Х. , Гончаров И.Н. , Колотева М.И. , Гончарова А.Г. , Каширина Д.Н. , Носовский А.М. , Глебова Т.М. , Kononikhin A.S. , Borchers C.H. , Nikolaev E.N. , Ларина И.М.
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions
Life Sciences in Space Research. 2022. №33. С.7-12. DOI: 10.1016/j.lssr.2022.01.001 WOS Scopus РИНЦ PMID OpenAlex

Web of science:	WOS:000754779400002
Scopus:	2-s2.0-85124214041
РИНЦ:	48148490
PMID (PubMed):	35491032
OpenAlex:	W4213175745

БД	Цитирований
Scopus	1