Sleep and autonomic nervous system during a 4-months isolation experiment Тезисы доклада
Конференция |
XXIII International symposium Human in Space 05-08 апр. 2021 , Москва |
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Журнал |
Авиакосмическая и экологическая медицина
ISSN: 0233-528X |
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Вых. Данные | Год: 2021, Том: 55, Номер: 1/1, Страницы: 65 Страниц : 1 | ||||||
Авторы |
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Организации |
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Реферат:
Introduction. Short sleep and sleep alterations are highly prevalent due to irregular work shifts and extreme working conditions. Impaired sleep negatively affects sleep quality, cognitive performance, and the regeneration of the autonomic nervous system (ANS), leading to autonomic stress, morbidity and mortality. A special group with a high sleep deficiency are astronauts due to strenuous physical and mental workload and extreme exogenous conditions that cause a dysregulation of the circadian rhythm and sleep-wake cycle in outer space. A cooperation IMBP with ICSM was formed to identify a way to predict performance ability of astronauts after impaired sleep. As part of the MANSA project (Modulation of cardiac autonomous nervous system activity by a simulated 4-month outer space transit-phase mission), we aimed to identify noninvasive biomarkers of the ANS that capture the effects of impaired sleep. Methods. During our pilot study (ANSISS), a study protocol to measure ANS parameters with the Somnotouch RESP was developed, the smallest and lightest portable non-invasive polygraphy system currently available and employable in space. Now, the protocol and the Somnotouch RESP were implemented during a four months isolation experiment of SIRIUS-19, simulating an outer space transit phase mission. A within-subject design was applied with the six participants (3 men/ 3 women, age 34 ± 6 years). They were recorded at eight timepoints experiencing different sleeping conditions: 1x premission and 1x post-mission (undisturbed sleep), 1x post-mission (undisturbed sleep), 6x during mission with undisturbed sleep (3x), complete sleep deprivation (1x), low sleep fragmentation (1x with waking up once for one hour), and high sleep fragmentation (1x with waking up five short times). ANS parameters were recorded with the Somnotouch RESP and sleep with a 1-channel EEG electrode attached to the forehead and sleep questionnaires. Results. Subjective sleep data indicated subjects were most tired after sleep impaired nights, especially the night without sleep. Objective sleep data showed significantly reduced sleep efficiency during sleep impaired nights (p < 0.01) with a mean sleep efficiency of 65 ± 17 % during high sleep fragmentation and 77 ± 6 % during low sleep fragmentation. The LF/HF (low-to-high frequency spectral power ratio) - a parameter of the heart rate variability - was significantly increased during the night without sleep (p < 0.001, mean LF/HF=2.27 ± 0.7) while the other nights did not significantly differ (mean LF/HF range: minimum=1.31±0.4; maximum=1.85±0.4). Preliminary sleep stage data of mean heart rate, pulse rate and LF/HF showed a normal progression during the night with being lowest during deep sleep and an increase during REM sleep (dream sleep) for all nights, including the nights with sleep impairment. Conclusion. The results reveal the strongest effects for the night with complete sleep deprivation. The increase of the LF/ HF ratio indicates a lack of ANS regeneration. Heart rate variability parameters recorded with the Somnotouch RESP may be suitable ANS biomarkers to capture effects of impaired sleep parameter. However, the results also revealed that the subjects’ ANS was in general quite robust towards subjectively and objectively impaired sleep. Further analyses are currently being conducted.
Библиографическая ссылка:
Laharnar N.
, Glos M.
, Suvorov A.V.
, Demin A.V.
, Penzel T.
, Fietze I.
Sleep and autonomic nervous system during a 4-months isolation experiment
Авиакосмическая и экологическая медицина. 2021. V.55. N1/1. P.65.
Sleep and autonomic nervous system during a 4-months isolation experiment
Авиакосмическая и экологическая медицина. 2021. V.55. N1/1. P.65.
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